発達エンハンサーのエピジェネティックな不活性化はSOX2の過剰発現を促進します
New Results Luis E. Abatti, Patricia Lado-Fernández, Linh Huynh, Manuel Collado, View ORCID ProfileMichael M. Hoffman, View ORCID ProfileJennifer A. Mitchell doi: https://doi.org/10.1101/2023.03.14.532258 ABSTRACTEnhancer reprogramming has been proposed as a major source of gene expression dysregulation during tumorigenesis. Here, we identify SOX2 developmental enhancers that are misactivated in breast and lung carcinoma. Deletion of the…